| Gender-bending
chemicals that mimic the effect of oestrogen are common in sunscreens, warns
a team of Swiss researchers who have found that they trigger developmental
abnormalities in rats. "We need to do more tests to see how they might
be affecting people," says Margaret Schlumpf from the Institute of
Pharmacology and Toxicology at the University of Zurich, Switzerland. Researchers
know that chemicals which behave like oestrogen can cause health problems.
They can have a dramatic effect on animals, for example turning fish into
hermaphrodites. Some researchers claim that hormonally active chemicals
from the urine of women taking the birth control pill are already swamping
the environment, and may be causing a decline in sperm counts.
Uterine growth
Schlumpf and her colleagues tested six common UV screening chemicals used
in sunscreens, lipsticks and other cosmetics. All five UVB screens -benzophenone-3,
homosalate, 4-methyl-benzylidene camphor (4-MBC), octyl-methoxycinnamate
and octyl-dimethyl-PABA - behaved like oestrogen in lab tests, making
cancer cells grow more rapidly. Three caused developmental effects in
animals. Only one chemical - a UVA protector called butyl-methoxydibenzoylmethane
(B-MDM) - showed no activity. One of the most common sunscreen chemicals,
4-MBC, had a particularly strong effect. When the team mixed it with olive
oil and applied it to rat skin, it doubled the rate of uterine growth
well before puberty. "That was scary, because we used concentrations
that are in the range allowed in sunscreens," Schlumpf says. Nobody
knows if doses are high enough to create problems for people, says Schlumpf.
Low levels
"Evidence that they're a real health concern is still lacking,"
says Richard Sharpe from the Medical Research Council's Reproductive Biology
Unit in Edinburgh. But he adds, "It's not good news that we are lathering
ourselves with creams with hormonal activity." The Cosmetic Toiletry
& Perfumery Association, which represents sunscreen manufacturers
in Britain, replies that the levels found by Schlumpf are well below anything
that would cause an effect after a single application. A study by the
association, not yet published, shows no effect from these chemicals in
rats. But, it adds, "If levels are increasing [in the environment]
then we're aware something would have to be done soon."
Breast milk
That day may be here since 4-MBC and other sunscreen chemicals have been
shown to accumulate in fish from lakes where people swim. More worryingly,
they have been found in breast milk at levels of nanograms per kilogram
of fat - about the same as other known environmental contaminants. Schlumpf
worries that the large amount of sunscreen used by bathers, especially
children, could dramatically increase this exposure. Schlumpf says the
other 25 or so chemicals used in sunscreens should also be tested for
hormonal activity, and she will be looking more closely at 4-MBC to see
if the offspring of exposed rats develop health problems.
For the moment, she
isn't advising people to ditch sunscreens completely, but suggests that
sunblocks like zinc oxide might make a healthier alternative.
More at: Environmental
Health Perspectives
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