Melissa
Kaplan's
Chronic Neuroimmune Diseases
Information on CFS, FM, MCS, Lyme Disease, Thyroid, and more...
Last updated
January 1, 2014
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Melissa
Kaplan's |
Epstein-Barr Virus and Chronic Fatigue Syndrome
Normal virus load in blood and normal immunologic areactivity in the EBV regression assay
Swanink, CM et al. Clin Infect Dis 20(5):1390-2; 20 May 1995
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etiology of chronic fatigue syndrome (CFS) is unknown. Some patients have
high antibody titers to viral capsid antigen (VCA) and early antigen (EA)
of Epstein-Barr virus (EBV), suggesting that reactivation of EBV is involved.
We investigated virus load (spontaneous transformation) and immunologic
regression of EBV-induced transformation in peripheral blood mononuclear
cells (PBMCs) from 10 selected patients with CFS who had high antibody titers
to VCA and EA. The outcome was compared with that for nine healthy controls
and one patient with severe chronic active EBV infection (SCAEBV). There
were no significant differences in viral load between patients and healthy
controls. Immunologic regression of in vitro-transformed PBMCs was also
equally efficient in patients and controls. The SCAEBV-infected patient
and two controls, who were all seronegative for EBV, showed impaired regression.
In conclusion, we were unable to demonstrate a role for reactivation of
EBV in CFS, even in selected patients with high titers of antibody to VCA
and EA of EBV.
For testing, see AAL
Reference Lab, Inc.'s Chronic
Fatigue Syndrome Panel (Test #2700)
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http://www.anapsid.org/cnd/filename.html
© 1994-2014 Melissa Kaplan or as otherwise noted by other authors of articles on this site
